Comparative study of the inhibitory effect on bone erosion progression with denosumab treatment and conventional treatment in rheumatoid arthritis patients: study protocol for an open-label randomized controlled trial by HR-pQCT

Comparative study of the inhibitory effect on bone erosion progression with denosumab treatment and conventional treatment in rheumatoid arthritis patients: study protocol for an open-label randomized controlled trial by HR-pQCT

Abstract Background Rheumatoid arthritis (RA) is a chronic inflammatory disease of the joints, causes joint destruction, and leads to physical disability. Advances in the treatment of RA, such as biologic disease-modifying anti-rheumatic drugs (DMARDs), have provided better clinical outcomes, includ...

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Bibliographic Details
Main Authors: Naoki Iwamoto, Shuntaro Sato, Remi Sumiyoshi, Ko Chiba, Nanami Miyamoto, Kumiko Arinaga, Makiko Kobayashi, Hiroshi Yamamoto, Makoto Osaki, Atsushi Kawakami
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Trials
Subjects:
Rheumatoid arthritis
RANKL
Denosumab
Bone erosion
Bone micro-architecture
HR-pQCT
Online Access:http://link.springer.com/article/10.1186/s13063-019-3589-8

Internet

http://link.springer.com/article/10.1186/s13063-019-3589-8

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