Imaging mass cytometry reveals generalised deficiency in OXPHOS complexes in Parkinson’s disease

Imaging mass cytometry reveals generalised deficiency in OXPHOS complexes in Parkinson’s disease

Abstract Here we report the application of a mass spectrometry-based technology, imaging mass cytometry, to perform in-depth proteomic profiling of mitochondrial complexes in single neurons, using metal-conjugated antibodies to label post-mortem human midbrain sections. Mitochondrial dysfunction, pa...

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Bibliographic Details
Main Authors: Chun Chen, David McDonald, Alasdair Blain, Ashwin Sachdeva, Laura Bone, Anna L. M. Smith, Charlotte Warren, Sarah J. Pickett, Gavin Hudson, Andrew Filby, Amy E. Vincent, Doug M. Turnbull, Amy K. Reeve
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-021-00182-x

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https://doi.org/10.1038/s41531-021-00182-x

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