Hypertonia-linked protein Trak1 functions with mitofusins to promote mitochondrial tethering and fusion

Hypertonia-linked protein Trak1 functions with mitofusins to promote mitochondrial tethering and fusion

ABSTRACT Hypertonia is a neurological dysfunction associated with a number of central nervous system disorders, including cerebral palsy, Parkinson’s disease, dystonia, and epilepsy. Genetic studies have identified a homozygous truncation mutation in Trak1 that causes hypertonia in mice. Moreover, e...

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Bibliographic Details
Main Authors: Crystal A. Lee, Lih-Shen Chin, Lian Li
Format: Article
Language:English
Published: SpringerOpen 2017-09-01
Series:Protein & Cell
Subjects:
mitochondria
mitochondrial fusion
mitochondrial tethering
mitofusin
hypertonia
Online Access:http://link.springer.com/article/10.1007/s13238-017-0469-4

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http://link.springer.com/article/10.1007/s13238-017-0469-4

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