α4-containing GABAA receptors are required for antagonism of ethanol-induced motor incoordination and hypnosis by the imidazobenzodiazepine Ro15-4513

α4-containing GABAA receptors are required for antagonism of ethanol-induced motor incoordination and hypnosis by the imidazobenzodiazepine Ro15-4513

Alcohol (ethanol) is widely consumed for its desirable effects but unfortunately has strong addiction potential. Some imidazobenzodiazepines such as Ro15-4513 are able to antagonize many ethanol-induced behaviors. Controversial biochemical and pharmacological evidence suggest that the effects of th...

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Bibliographic Details
Main Authors: Sangeetha V. Iyer, Rodrigo eBenavides, Dev eChandra, James M Cook, Sundari eRallapalli, Harry L. June, Gregg E Homanics
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-04-01
Series:Frontiers in Pharmacology
Subjects:
benzodiazepine
alcohol
alcohol antagonist
alcohol receptor
extrasynaptic GABAa receptor
Ro15-4513
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00018/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00018/full

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