Loss of FoxO3a prevents aortic aneurysm formation through maintenance of VSMC homeostasis

Loss of FoxO3a prevents aortic aneurysm formation through maintenance of VSMC homeostasis

Abstract Vascular smooth muscle cell (VSMC) phenotypic switching plays a critical role in the formation of abdominal aortic aneurysms (AAAs). FoxO3a is a key suppressor of VSMC homeostasis. We found that in human and animal AAA tissues, FoxO3a was upregulated, SM22α and α-smooth muscle actin (α-SMA)...

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Bibliographic Details
Main Authors: Weiling Lu, Yu Zhou, Shan Zeng, Lintao Zhong, Shiju Zhou, Haoyu Song, Rongming Ding, Gaojun Zhong, Qingrui Li, Yuhua Hu, Zhongyu Wen, Qin Liao, Yalan Wang, Lianglliang Lyu, Yiming Zhong, Gonghua Hu, Yulin Liao, Dongming Xie, Jiahe Xie
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03659-y

Internet

https://doi.org/10.1038/s41419-021-03659-y

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