Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division

Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division

Dynamin-related protein 1 (Drp1) divides mitochondria as a mechano-chemical GTPase. However, the function of Drp1 beyond mitochondrial division is largely unknown. Multiple Drp1 isoforms are produced through mRNA splicing. One such isoform, Drp1ABCD, contains all four alternative exons and is specif...

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Bibliographic Details
Main Authors: Kie Itoh, Daisuke Murata, Takashi Kato, Tatsuya Yamada, Yoichi Araki, Atsushi Saito, Yoshihiro Adachi, Atsushi Igarashi, Shuo Li, Mikhail Pletnikov, Richard L Huganir, Shigeki Watanabe, Atsushi Kamiya, Miho Iijima, Hiromi Sesaki
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-10-01
Series:eLife
Subjects:
Drp1
endocytosis
brain
mitochondria
Online Access:https://elifesciences.org/articles/44739

Internet

https://elifesciences.org/articles/44739

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