CHARMM Force Field Parameterization of Peroxisome Proliferator-Activated Receptor γ Ligands

CHARMM Force Field Parameterization of Peroxisome Proliferator-Activated Receptor γ Ligands

The peroxisome proliferator-activated receptor γ (PPARγ) ligands are important therapeutic drugs for the treatment of type 2 diabetes, obesity and cardiovascular diseases. In particular, partial agonists and non-agonists are interesting targets to reduce glucose levels, presenting few side effects i...

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Bibliographic Details
Main Authors: Melina Mottin, Paulo C. T. Souza, Clarisse G. Ricci, Munir S. Skaf
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:International Journal of Molecular Sciences
Subjects:
PPARγ ligands
nuclear receptor
CHARMM parameters
molecular dynamics
GQ16
SR1664
Online Access:http://www.mdpi.com/1422-0067/18/1/15

Internet

http://www.mdpi.com/1422-0067/18/1/15

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