cAMP Receptor Protein Positively Regulates the Expression of Genes Involved in the Biosynthesis of Klebsiella oxytoca Tilivalline Cytotoxin

cAMP Receptor Protein Positively Regulates the Expression of Genes Involved in the Biosynthesis of Klebsiella oxytoca Tilivalline Cytotoxin

Klebsiella oxytoca is a resident of the human gut. However, certain K. oxytoca toxigenic strains exist that secrete the nonribosomal peptide tilivalline (TV) cytotoxin. TV is a pyrrolobenzodiazepine that causes antibiotic-associated hemorrhagic colitis (AAHC). The biosynthesis of TV is driven by enz...

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Bibliographic Details
Main Authors: Diana Rodríguez-Valverde, Nancy León-Montes, Jorge Soria-Bustos, Jessica Martínez-Cruz, Ricardo González-Ugalde, Sandra Rivera-Gutiérrez, Jorge A. González-y-Merchand, Roberto Rosales-Reyes, Lázaro García-Morales, Hidetada Hirakawa, James G. Fox, Jorge A. Girón, Miguel A. De la Cruz, Miguel A. Ares
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Microbiology
Subjects:
CRP
tilivalline cytotoxin
aroX
npsA
Klebsiella oxytoca
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.743594/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.743594/full

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