Sephin1 Protects Neurons against Excitotoxicity Independently of the Integrated Stress Response

Sephin1 Protects Neurons against Excitotoxicity Independently of the Integrated Stress Response

Sephin1 is a derivative of guanabenz that inhibits the dephosphorylation of the eukaryotic initiation factor 2 alpha (eIF2α) and therefore may enhance the integrated stress response (ISR), an adaptive mechanism against different cellular stresses, such as accumulation of misfolded proteins. Unlike g...

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Bibliographic Details
Main Authors: Asier Ruiz, Jone Zuazo, Carolina Ortiz-Sanz, Celia Luchena, Carlos Matute, Elena Alberdi
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
excitotoxicity
integrated stress response
calpain
Sephin1
guanabenz
calcium
Online Access:https://www.mdpi.com/1422-0067/21/17/6088

Internet

https://www.mdpi.com/1422-0067/21/17/6088

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