Pseudoginsengenin DQ Exhibits Therapeutic Effects in Cisplatin-Induced Acute Kidney Injury via Sirt1/NF-κB and Caspase Signaling Pathway without Compromising Its Antitumor Activity in Mice

Pseudoginsengenin DQ Exhibits Therapeutic Effects in Cisplatin-Induced Acute Kidney Injury via Sirt1/NF-κB and Caspase Signaling Pathway without Compromising Its Antitumor Activity in Mice

In this study, the protective effects of pseudoginsengenin DQ (PDQ) on cisplatin (CDDP)-induced nephrotoxicity were assessed, with a primary investigation into the mechanisms involved. Our results showed that pretreatment with PDQ remarkably restored levels of blood urea nitrogen (BUN) and creatinin...

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Bibliographic Details
Main Authors: Zeng Qi, Zhuo Li, Wei Li, Yunhe Liu, Cuizhu Wang, Hongqiang Lin, Jinping Liu, Pingya Li
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
pseudoginsengenin DQ
CDDP-induced acute kidney injury
Sirt1/NF-κB
caspase
Online Access:https://www.mdpi.com/1420-3049/23/11/3038

Internet

https://www.mdpi.com/1420-3049/23/11/3038

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