Synthesis and Biological Evaluation of New Pleuromutilin Derivatives as Antibacterial Agents

Synthesis and Biological Evaluation of New Pleuromutilin Derivatives as Antibacterial Agents

Several pleuromutilin derivatives possessing thiadiazole moieties were synthesized via acylation reactions under mild conditions. The in vitro antibacterial activities of the derivatives against methicillin-resistant S. aureus, methicillin-resistant S. epidermidis, S. aureus, S. epidermidis, E. col...

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Bibliographic Details
Main Authors: Ruo-Feng Shang, Guan-Hua Wang, Xi-Ming Xu, Si-Jie Liu, Chao Zhang, Yun-Peng Yi, Jian-Ping Liang, Yu Liu
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Molecules
Subjects:
pleuromutilin derivatives
antibacterial activity
synthesis
molecular docking
ADMET properties
Online Access:http://www.mdpi.com/1420-3049/19/11/19050

Internet

http://www.mdpi.com/1420-3049/19/11/19050

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