Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia
Chronic lymphocytic leukaemia (CLL) is characterized by cell-autonomous B-cell receptor (BcR)-mediated signalling of neoplastic B lymphocytes. Here the authors unveil the structural basis and diversity of activatory homotypic BcR contacts and link them with CLL heterogeneity and the clinical outcome...
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Bibliographic Details
Main Authors: |
Claudia Minici,
Maria Gounari,
Rudolf Übelhart,
Lydia Scarfò,
Marcus Dühren-von Minden,
Dunja Schneider,
Alpaslan Tasdogan,
Alabbas Alkhatib,
Andreas Agathangelidis,
Stavroula Ntoufa,
Nicholas Chiorazzi,
Hassan Jumaa,
Kostas Stamatopoulos,
Paolo Ghia,
Massimo Degano |
Format: | Article
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Language: | English |
Published: |
Nature Publishing Group
2017-06-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/ncomms15746
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