Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia

Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia

Chronic lymphocytic leukaemia (CLL) is characterized by cell-autonomous B-cell receptor (BcR)-mediated signalling of neoplastic B lymphocytes. Here the authors unveil the structural basis and diversity of activatory homotypic BcR contacts and link them with CLL heterogeneity and the clinical outcome...

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Main Authors: Claudia Minici, Maria Gounari, Rudolf Übelhart, Lydia Scarfò, Marcus Dühren-von Minden, Dunja Schneider, Alpaslan Tasdogan, Alabbas Alkhatib, Andreas Agathangelidis, Stavroula Ntoufa, Nicholas Chiorazzi, Hassan Jumaa, Kostas Stamatopoulos, Paolo Ghia, Massimo Degano
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15746
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spelling doaj-d134c066cc4e4ceb916cfd21f5f035002021-05-11T07:47:30ZengNature Publishing GroupNature Communications2041-17232017-06-018111210.1038/ncomms15746Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemiaClaudia Minici0Maria Gounari1Rudolf Übelhart2Lydia Scarfò3Marcus Dühren-von Minden4Dunja Schneider5Alpaslan Tasdogan6Alabbas Alkhatib7Andreas Agathangelidis8Stavroula Ntoufa9Nicholas Chiorazzi10Hassan Jumaa11Kostas Stamatopoulos12Paolo Ghia13Massimo Degano14Division of Immunology, Biocrystallography Unit, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific InstituteDivision of Experimental Oncology, B-cell Neoplasia Unit, IRCCS San Raffaele Scientific InstituteUniversitätsklinik UlmUniversità Vita-Salute San RaffaeleUniversitätsklinik UlmCentre for Biological Signaling Studies, Faculty of Biology, Albert-Ludwigs University of FreiburgUniversitätsklinik UlmCentre for Biological Signaling Studies, Faculty of Biology, Albert-Ludwigs University of FreiburgDivision of Experimental Oncology, B-cell Neoplasia Unit, IRCCS San Raffaele Scientific InstituteInstitute of Applied Biosciences, Center for Research and TechnologyThe Feinstein Institute for Medical ResearchUniversitätsklinik UlmInstitute of Applied Biosciences, Center for Research and TechnologyUniversità Vita-Salute San RaffaeleDivision of Immunology, Biocrystallography Unit, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific InstituteChronic lymphocytic leukaemia (CLL) is characterized by cell-autonomous B-cell receptor (BcR)-mediated signalling of neoplastic B lymphocytes. Here the authors unveil the structural basis and diversity of activatory homotypic BcR contacts and link them with CLL heterogeneity and the clinical outcome.https://doi.org/10.1038/ncomms15746
collection DOAJ
language English
format Article
sources DOAJ
author Claudia Minici
Maria Gounari
Rudolf Übelhart
Lydia Scarfò
Marcus Dühren-von Minden
Dunja Schneider
Alpaslan Tasdogan
Alabbas Alkhatib
Andreas Agathangelidis
Stavroula Ntoufa
Nicholas Chiorazzi
Hassan Jumaa
Kostas Stamatopoulos
Paolo Ghia
Massimo Degano
spellingShingle Claudia Minici
Maria Gounari
Rudolf Übelhart
Lydia Scarfò
Marcus Dühren-von Minden
Dunja Schneider
Alpaslan Tasdogan
Alabbas Alkhatib
Andreas Agathangelidis
Stavroula Ntoufa
Nicholas Chiorazzi
Hassan Jumaa
Kostas Stamatopoulos
Paolo Ghia
Massimo Degano
Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia
Nature Communications
author_facet Claudia Minici
Maria Gounari
Rudolf Übelhart
Lydia Scarfò
Marcus Dühren-von Minden
Dunja Schneider
Alpaslan Tasdogan
Alabbas Alkhatib
Andreas Agathangelidis
Stavroula Ntoufa
Nicholas Chiorazzi
Hassan Jumaa
Kostas Stamatopoulos
Paolo Ghia
Massimo Degano
author_sort Claudia Minici
title Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia
title_short Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia
title_full Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia
title_fullStr Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia
title_full_unstemmed Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia
title_sort distinct homotypic b-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-06-01
description Chronic lymphocytic leukaemia (CLL) is characterized by cell-autonomous B-cell receptor (BcR)-mediated signalling of neoplastic B lymphocytes. Here the authors unveil the structural basis and diversity of activatory homotypic BcR contacts and link them with CLL heterogeneity and the clinical outcome.
url https://doi.org/10.1038/ncomms15746
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