MultiK: an automated tool to determine optimal cluster numbers in single-cell RNA sequencing data

MultiK: an automated tool to determine optimal cluster numbers in single-cell RNA sequencing data

Abstract Single-cell RNA sequencing (scRNA-seq) provides new opportunities to characterize cell populations, typically accomplished through some type of clustering analysis. Estimation of the optimal cluster number (K) is a crucial step but often ignored. Our approach improves most current scRNA-seq...

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Bibliographic Details
Main Authors: Siyao Liu, Aatish Thennavan, Joseph P. Garay, J. S. Marron, Charles M. Perou
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Genome Biology
Subjects:
Single-cell RNA-seq
Clustering
Multi-scale
Multi-resolution
Genomics
Reproducibility
Online Access:https://doi.org/10.1186/s13059-021-02445-5

Internet

https://doi.org/10.1186/s13059-021-02445-5

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