Additive Effects of PS1 and APP Mutations on Secretion of the 42-Residue Amyloid β-Protein

Additive Effects of PS1 and APP Mutations on Secretion of the 42-Residue Amyloid β-Protein

Humans harboring missense mutations in the presenilin 1 (PS1) gene undergo progressive cerebral deposition of the 42-residue amyloid β-protein (Aβ42) at an early age and develop severe Alzheimer's disease. Aβ42is selectively elevated in the conditioned media of cells expressing mutant but not w...

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Bibliographic Details
Main Authors: Martin Citron, Christopher B. Eckman, Thekla S. Diehl, Chris Corcoran, Beth L. Ostaszewski, Weiming Xia, Georges Levesque, Peter St. George Hyslop, Steven G. Younkin, Dennis J. Selkoe
Format: Article
Language:English
Published: Elsevier 1998-08-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996198901838

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http://www.sciencedirect.com/science/article/pii/S0969996198901838

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