Alteration of gene expression profile in Niemann-Pick type C mice correlates with tissue damage and oxidative stress.

Alteration of gene expression profile in Niemann-Pick type C mice correlates with tissue damage and oxidative stress.

BACKGROUND: Niemann-Pick type C disease (NPC) is a neurovisceral lipid storage disorder mainly characterized by unesterified cholesterol accumulation in lysosomal/late endosomal compartments, although there is also an important storage for several other kind of lipids. The main tissues affected by t...

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Bibliographic Details
Main Authors: Mary C Vázquez, Talía del Pozo, Fermín A Robledo, Gonzalo Carrasco, Leonardo Pavez, Felipe Olivares, Mauricio González, Silvana Zanlungo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3245218?pdf=render

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http://europepmc.org/articles/PMC3245218?pdf=render

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