Alteration of gene expression profile in Niemann-Pick type C mice correlates with tissue damage and oxidative stress.
BACKGROUND: Niemann-Pick type C disease (NPC) is a neurovisceral lipid storage disorder mainly characterized by unesterified cholesterol accumulation in lysosomal/late endosomal compartments, although there is also an important storage for several other kind of lipids. The main tissues affected by t...
Main Authors: | Mary C Vázquez, Talía del Pozo, Fermín A Robledo, Gonzalo Carrasco, Leonardo Pavez, Felipe Olivares, Mauricio González, Silvana Zanlungo |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3245218?pdf=render |
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