Synthesis and Biological Evaluation of <i>NH</i><sub>2</sub>-Sulfonyl Oseltamivir Analogues as Influenza Neuraminidase Inhibitors

Synthesis and Biological Evaluation of <i>NH</i><sub>2</sub>-Sulfonyl Oseltamivir Analogues as Influenza Neuraminidase Inhibitors

A series of <i>NH</i><sub>2</sub>-sulfonyl oseltamivir analogues were designed, synthesized, and their inhibitory activities against neuraminidase from H5N1 subtype evaluated. The results indicated that the IC<sub>50</sub> value of compound <b>4a</b>,...

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Bibliographic Details
Main Authors: Yaping Hu, Binfeng Chen, Zaiqiang Lei, Hongqian Zhao, Hongxi Zhu, Peng Quan, Yongshou Tian
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
influenza
neuraminidase inhibitors
oseltamivir analogues
Online Access:https://www.mdpi.com/1420-3049/24/11/2176

Internet

https://www.mdpi.com/1420-3049/24/11/2176

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