AP-1 Oligodeoxynucleotides Reduce Aortic Elastolysis in a Murine Model of Marfan Syndrome

AP-1 Oligodeoxynucleotides Reduce Aortic Elastolysis in a Murine Model of Marfan Syndrome

Marfan syndrome is characterized by high expression of matrix metalloproteinases (MMPs) in aortic smooth muscle cells (AoSMCs) associated with medial elastolysis and aortic root aneurysm. We aimed to reduce aortic elastolysis through decrease of MMP expression with decoy oligodeoxynucleotides (dODNs...

Full description

Bibliographic Details
Main Authors: Rawa Arif, Marcin Zaradzki, Anca Remes, Philipp Seppelt, Reiner Kunze, Hannes Schröder, Simon Schwill, Stephan M. Ensminger, Peter N. Robinson, Matthias Karck, Oliver J. Müller, Markus Hecker, Andreas H. Wagner, Klaus Kallenbach
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
Marfan syndrome
matrix metalloproteinases
AP-1
aneurysm
aorta
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117302421

Internet

http://www.sciencedirect.com/science/article/pii/S2162253117302421

Similar Items