Mitochondrial Dysfunction in Astrocytes Impairs the Generation of Reactive Astrocytes and Enhances Neuronal Cell Death in the Cortex Upon Photothrombotic Lesion

Mitochondrial Dysfunction in Astrocytes Impairs the Generation of Reactive Astrocytes and Enhances Neuronal Cell Death in the Cortex Upon Photothrombotic Lesion

Mitochondria are key organelles in regulating the metabolic state of a cell. In the brain, mitochondrial oxidative metabolism is the prevailing mechanism for neurons to generate ATP. While it is firmly established that neuronal function is highly dependent on mitochondrial metabolism, it is less wel...

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Bibliographic Details
Main Authors: Christian Fiebig, Silke Keiner, Birgit Ebert, Iris Schäffner, Ravi Jagasia, D. Chichung Lie, Ruth Beckervordersandforth
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
mitochondrial metabolism
astrocytes
stroke/photothrombotic lesion
electron transport chain
oxidative phosphorylation
reactive gliosis
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00040/full

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https://www.frontiersin.org/article/10.3389/fnmol.2019.00040/full

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