Bile acid metabolism and signaling in liver disease and therapy
Bile acids play a critical role in the regulation of glucose, lipid, and energy metabolism through activation of the nuclear bile acid receptor farnesoid X receptor (FXR) and membrane G protein-coupled bile acid receptor-1 (Gpbar-1, aka TGR5). Agonist activation of FXR and TGR5 improves insulin and...
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KeAi Communications Co., Ltd.
2017-06-01
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Series: | Liver Research |
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doaj-d1541a2a6c024be88b87a27f79976b7a2021-03-02T10:37:01ZengKeAi Communications Co., Ltd.Liver Research2542-56842017-06-011139Bile acid metabolism and signaling in liver disease and therapyJohn Y.L. Chiang0Department of Integrative Medical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, OH, USABile acids play a critical role in the regulation of glucose, lipid, and energy metabolism through activation of the nuclear bile acid receptor farnesoid X receptor (FXR) and membrane G protein-coupled bile acid receptor-1 (Gpbar-1, aka TGR5). Agonist activation of FXR and TGR5 improves insulin and glucose sensitivity and stimulates energy metabolism to prevent diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD). Bile acids have both pro- and anti-inflammatory actions through FXR and TGR5 in the intestine and liver. In the intestine, bile acids activate FXR and TGR5 to stimulate fibroblast growth factor 15 and glucagon-like peptide-1 secretion. FXR and TGR5 agonists may have therapeutic potential for treating liver-related metabolic diseases, such as diabetes and NAFLD. Keywords: Bile acid metabolism, Cholestatic liver diseases, Metabolic diseaseshttp://www.sciencedirect.com/science/article/pii/S2542568417000071 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
John Y.L. Chiang |
spellingShingle |
John Y.L. Chiang Bile acid metabolism and signaling in liver disease and therapy Liver Research |
author_facet |
John Y.L. Chiang |
author_sort |
John Y.L. Chiang |
title |
Bile acid metabolism and signaling in liver disease and therapy |
title_short |
Bile acid metabolism and signaling in liver disease and therapy |
title_full |
Bile acid metabolism and signaling in liver disease and therapy |
title_fullStr |
Bile acid metabolism and signaling in liver disease and therapy |
title_full_unstemmed |
Bile acid metabolism and signaling in liver disease and therapy |
title_sort |
bile acid metabolism and signaling in liver disease and therapy |
publisher |
KeAi Communications Co., Ltd. |
series |
Liver Research |
issn |
2542-5684 |
publishDate |
2017-06-01 |
description |
Bile acids play a critical role in the regulation of glucose, lipid, and energy metabolism through activation of the nuclear bile acid receptor farnesoid X receptor (FXR) and membrane G protein-coupled bile acid receptor-1 (Gpbar-1, aka TGR5). Agonist activation of FXR and TGR5 improves insulin and glucose sensitivity and stimulates energy metabolism to prevent diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD). Bile acids have both pro- and anti-inflammatory actions through FXR and TGR5 in the intestine and liver. In the intestine, bile acids activate FXR and TGR5 to stimulate fibroblast growth factor 15 and glucagon-like peptide-1 secretion. FXR and TGR5 agonists may have therapeutic potential for treating liver-related metabolic diseases, such as diabetes and NAFLD. Keywords: Bile acid metabolism, Cholestatic liver diseases, Metabolic diseases |
url |
http://www.sciencedirect.com/science/article/pii/S2542568417000071 |
work_keys_str_mv |
AT johnylchiang bileacidmetabolismandsignalinginliverdiseaseandtherapy |
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