LonP1 Differently Modulates Mitochondrial Function and Bioenergetics of Primary Versus Metastatic Colon Cancer Cells

LonP1 Differently Modulates Mitochondrial Function and Bioenergetics of Primary Versus Metastatic Colon Cancer Cells

Mitochondrial Lon protease (LonP1) is a multi-function enzyme that regulates mitochondrial functions in several human malignancies, including colorectal cancer (CRC). The mechanism(s) by which LonP1 contributes to colorectal carcinogenesis is not fully understood. We found that silencing LonP1 leads...

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Bibliographic Details
Main Authors: Lara Gibellini, Lorena Losi, Sara De Biasi, Milena Nasi, Domenico Lo Tartaro, Simone Pecorini, Simone Patergnani, Paolo Pinton, Anna De Gaetano, Gianluca Carnevale, Alessandra Pisciotta, Francesco Mariani, Luca Roncucci, Anna Iannone, Andrea Cossarizza, Marcello Pinti
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Oncology
Subjects:
LonP1
mitochondria
bioenergetics
beta-catenin
colorectal cancer
protease
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00254/full

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https://www.frontiersin.org/article/10.3389/fonc.2018.00254/full

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