Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse
How Nodal and Bmp pathways interact during primordial germ cell (PGC) formation remains unclear. Here, the authors show Nodal signalling via Eomes in the epiblast, together with Smad2 in the visceral endoderm, regulates formation of the mouse PGC lineage, while Smad1 specifies PGCs and Smad4 control...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09052-w |