Immunoglobulin G Fragment Crystallizable Glycosylation After Hematopoietic Stem Cell Transplantation Is Dissimilar to Donor Profiles

Immunoglobulin G Fragment Crystallizable Glycosylation After Hematopoietic Stem Cell Transplantation Is Dissimilar to Donor Profiles

Immunoglobulin G (IgG) fragment crystallizable (Fc) N-glycosylation has a large influence on the affinity of the antibody for binding to Fcγ-receptors (FcγRs) and C1q protein, thereby influencing immune effector functions. IgG Fc glycosylation is known to be partly regulated by genetics and partly b...

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Bibliographic Details
Main Authors: Noortje de Haan, Maarten J. D. van Tol, Gertjan J. Driessen, Manfred Wuhrer, Arjan C. Lankester
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
immunoglobulin G
fragment crystallizable glycosylation
N-glycan
hematopoietic stem cell transplantation
immune reconstitution
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01238/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01238/full

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