A First-Time-In-Human Phase I Clinical Trial of Bispecific Antibody-Targeted, Paclitaxel-Packaged Bacterial Minicells.

A First-Time-In-Human Phase I Clinical Trial of Bispecific Antibody-Targeted, Paclitaxel-Packaged Bacterial Minicells.

We have harnessed a novel biological system, the bacterial minicell, to deliver cancer therapeutics to cancer cells. Preclinical studies showed that epidermal growth factor receptor (EGFR)-targeted, paclitaxel-loaded minicells (EGFRminicellsPac) have antitumor effects in xenograft models. To examine...

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Bibliographic Details
Main Authors: Benjamin J Solomon, Jayesh Desai, Mark Rosenthal, Grant A McArthur, Scott T Pattison, Stacey L Pattison, Jennifer MacDiarmid, Himanshu Brahmbhatt, Andrew M Scott
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4699457?pdf=render

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http://europepmc.org/articles/PMC4699457?pdf=render

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