Poly(ADP-ribose) Polymerase-1 in the Nervous System
Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme, activated by DNA strand breaks to participate in DNA repair. Overactivation of PARP by cellular insults depletes its substrate NAD+ and then ATP, leading to a major energy deficit and cell death. This mechanism appears to be prominent in va...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2000-08-01
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| Series: | Neurobiology of Disease |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996100903243 |