Molecular Crystal Forms of Antitubercular Ethionamide with Dicarboxylic Acids: Solid-State Properties and a Combined Structural and Spectroscopic Study

Molecular Crystal Forms of Antitubercular Ethionamide with Dicarboxylic Acids: Solid-State Properties and a Combined Structural and Spectroscopic Study

We report on the preparation, characterization, and bioavailability properties of three new crystal forms of ethionamide, an antitubercular agent used in the treatment of drug-resistant tuberculosis. The new adducts were obtained by combining the active pharmaceutical ingredient with three dicarboxy...

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Bibliographic Details
Main Authors: Simone Bordignon, Paolo Cerreia Vioglio, Elena Amadio, Federica Rossi, Emanuele Priola, Dario Voinovich, Roberto Gobetto, Michele R. Chierotti
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Pharmaceutics
Subjects:
ethionamide
cocrystal
solid-state NMR
dissolution
kryptoracemate
salt cocrystal
Online Access:https://www.mdpi.com/1999-4923/12/9/818

Internet

https://www.mdpi.com/1999-4923/12/9/818

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