Synthesis and Antiviral Bioactivities of α-Aminophosphonates Containing Alkoxyethyl Moieties

Synthesis and Antiviral Bioactivities of α-Aminophosphonates Containing Alkoxyethyl Moieties

A simple, efficient, and general method has been developed for the synthesis ofvarious α-aminophosphonate derivatives 4a-4l by treatment of substituted benzaldehydes andaniline with bis(2-methoxyethyl)- or bis(2-ethoxyethyl) phosphite under microwaveirradiation without solvents and catalysts. The...

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Bibliographic Details
Main Authors: Zhuo Chen, Linhong Jin, Guiping Ouyang, Ping Lu, Deyu Hu, Wei Xue, Song Yang, Gangfang Xu, Baoan Song, Kai Yan, Yingshu Xu
Format: Article
Language:English
Published: MDPI AG 2006-09-01
Series:Molecules
Subjects:
Aminophosphonates
microwave irradiation
synthesis
antiviral activity
Online Access:http://www.mdpi.com/1420-3049/11/9/666/
Description
Summary:A simple, efficient, and general method has been developed for the synthesis ofvarious α-aminophosphonate derivatives 4a-4l by treatment of substituted benzaldehydes andaniline with bis(2-methoxyethyl)- or bis(2-ethoxyethyl) phosphite under microwaveirradiation without solvents and catalysts. The products were characterized by elementalanalysis, IR, 1H-NMR, 13C- and 31P-NMR spectra. The X-ray crystallographic data of therepresentative compound 4l was determined. The new α-aminophosphonate derivatives werefound to possess moderate to good antiviral activity.
ISSN:1420-3049

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