Complex small-world regulatory networks emerge from the 3D organisation of the human genome

Complex small-world regulatory networks emerge from the 3D organisation of the human genome

Gene-regulatory networks are thought to be complex, and yet perturbation of just a few transcription factors (TFs) can have major consequences. Here the authors apply DNA polymer modelling and simulations to predict how 3D genome structure and TF-DNA interactions can give rise to transcriptional reg...

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Bibliographic Details
Main Authors: C. A. Brackley, N. Gilbert, D. Michieletto, A. Papantonis, M. C. F. Pereira, P. R. Cook, D. Marenduzzo
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25875-y

Internet

https://doi.org/10.1038/s41467-021-25875-y

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