Immunological markers for PML prediction in MS patients treated with natalizumab

Natalizumab, a monoclonal antibody recognizing the alpha4 integrin chain, has been approved for the treatment of active multiple sclerosis, but expose to the onset of a rare side effect, progressive multifocal leurokoencephalitis (PML). Estimating the individual risk of PML in natalizumab-treated pa...

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Bibliographic Details
Main Authors: Caroline eAntoniol, Bruno eStankoff
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Immunology
Subjects:
JCV
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00668/full