Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy
Increased copy number alterations, indicative of chromosomal instability, is associated with poor cancer outcome. Here, metastatic colorectal cancer patients displaying intermediate-high CIN associate with improved outcome following chemotherapy and bevacizumab treatment, suggesting CIN as a predict...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06567-6 |
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doaj-d17fc441244b44c587907023fe2c93dd2021-05-11T09:47:49ZengNature Publishing GroupNature Communications2041-17232018-10-019111610.1038/s41467-018-06567-6Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapyDominiek Smeets0Ian S. Miller1Darran P. O’Connor2Sudipto Das3Bruce Moran4Bram Boeckx5Timo Gaiser6Johannes Betge7Ana Barat8Rut Klinger9Nicole C. T. van Grieken10Chiara Cremolini11Hans Prenen12Massimiliano Mazzone13Jeroen Depreeuw14Orna Bacon15Bozena Fender16Joseph Brady17Bryan T. Hennessy18Deborah A. McNamara19Elaine Kay20Henk M. Verheul21Neerincx Maarten22William M. Gallagher23Verena Murphy24Jochen H. M. Prehn25Miriam Koopman26Cornelis J. A. Punt27Fotios Loupakis28Matthias P. A. Ebert29Bauke Ylstra30Diether Lambrechts31Annette T. Byrne32VIB Center for Cancer BiologyDepartment of Physiology & Medical Physics, Royal College of Surgeons in IrelandDepartment of Molecular and Cellular Therapeutics, Royal College of Surgeons in IrelandDepartment of Molecular and Cellular Therapeutics, Royal College of Surgeons in IrelandUCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College DublinVIB Center for Cancer BiologyInstitute of Pathology, University Medical Center Mannheim, University of HeidelbergDepartment of Medicine II, University Hospital Mannheim, Heidelberg UniversityDepartment of Physiology & Medical Physics, Royal College of Surgeons in IrelandUCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College DublinDepartment of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit AmsterdamDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Istituto Toscano TumoriDepartment of Oncology, University Hospital AntwerpVIB Center for Cancer BiologyVIB Center for Cancer BiologyDepartment of Physiology & Medical Physics, Royal College of Surgeons in IrelandOncoMark Limited, NovaUCDVeterinary Pathobiology, School of Veterinary Medicine, University College DublinDepartment of Surgery, Beaumont HospitalDepartment of Surgery, Beaumont HospitalDepartment of Pathology, Beaumont HospitalDepartment of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit AmsterdamDepartment of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit AmsterdamUCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College DublinCancer Trials IrelandDepartment of Physiology & Medical Physics, Royal College of Surgeons in IrelandDepartment of Medical Oncology, University Medical Center Utrecht, Utrecht UniversityDepartment of Medical Oncology, Amsterdam UMC, University of AmsterdamOncologia Medica 1, Istituto Oncologico Veneto, Istituto di Ricovero e Cura a Carattere Scientifico, IRCCSDepartment of Medicine II, University Hospital Mannheim, Heidelberg UniversityDepartment of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit AmsterdamVIB Center for Cancer BiologyDepartment of Physiology & Medical Physics, Royal College of Surgeons in IrelandIncreased copy number alterations, indicative of chromosomal instability, is associated with poor cancer outcome. Here, metastatic colorectal cancer patients displaying intermediate-high CIN associate with improved outcome following chemotherapy and bevacizumab treatment, suggesting CIN as a predictive biomarker.https://doi.org/10.1038/s41467-018-06567-6 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Dominiek Smeets Ian S. Miller Darran P. O’Connor Sudipto Das Bruce Moran Bram Boeckx Timo Gaiser Johannes Betge Ana Barat Rut Klinger Nicole C. T. van Grieken Chiara Cremolini Hans Prenen Massimiliano Mazzone Jeroen Depreeuw Orna Bacon Bozena Fender Joseph Brady Bryan T. Hennessy Deborah A. McNamara Elaine Kay Henk M. Verheul Neerincx Maarten William M. Gallagher Verena Murphy Jochen H. M. Prehn Miriam Koopman Cornelis J. A. Punt Fotios Loupakis Matthias P. A. Ebert Bauke Ylstra Diether Lambrechts Annette T. Byrne |
| spellingShingle |
Dominiek Smeets Ian S. Miller Darran P. O’Connor Sudipto Das Bruce Moran Bram Boeckx Timo Gaiser Johannes Betge Ana Barat Rut Klinger Nicole C. T. van Grieken Chiara Cremolini Hans Prenen Massimiliano Mazzone Jeroen Depreeuw Orna Bacon Bozena Fender Joseph Brady Bryan T. Hennessy Deborah A. McNamara Elaine Kay Henk M. Verheul Neerincx Maarten William M. Gallagher Verena Murphy Jochen H. M. Prehn Miriam Koopman Cornelis J. A. Punt Fotios Loupakis Matthias P. A. Ebert Bauke Ylstra Diether Lambrechts Annette T. Byrne Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy Nature Communications |
| author_facet |
Dominiek Smeets Ian S. Miller Darran P. O’Connor Sudipto Das Bruce Moran Bram Boeckx Timo Gaiser Johannes Betge Ana Barat Rut Klinger Nicole C. T. van Grieken Chiara Cremolini Hans Prenen Massimiliano Mazzone Jeroen Depreeuw Orna Bacon Bozena Fender Joseph Brady Bryan T. Hennessy Deborah A. McNamara Elaine Kay Henk M. Verheul Neerincx Maarten William M. Gallagher Verena Murphy Jochen H. M. Prehn Miriam Koopman Cornelis J. A. Punt Fotios Loupakis Matthias P. A. Ebert Bauke Ylstra Diether Lambrechts Annette T. Byrne |
| author_sort |
Dominiek Smeets |
| title |
Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy |
| title_short |
Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy |
| title_full |
Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy |
| title_fullStr |
Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy |
| title_full_unstemmed |
Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy |
| title_sort |
copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-10-01 |
| description |
Increased copy number alterations, indicative of chromosomal instability, is associated with poor cancer outcome. Here, metastatic colorectal cancer patients displaying intermediate-high CIN associate with improved outcome following chemotherapy and bevacizumab treatment, suggesting CIN as a predictive biomarker. |
| url |
https://doi.org/10.1038/s41467-018-06567-6 |
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