Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities

Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities

Rho-class small GTPases are implicated in basic cellular processes at nearly all brain developmental steps, from neurogenesis and migration to axon guidance and synaptic plasticity. GTPases are key signal transducing enzymes that link extracellular cues to the neuronal responses required for the con...

Full description

Bibliographic Details
Main Authors: Valentina Zamboni, Rebecca Jones, Alessandro Umbach, Alessandra Ammoni, Maria Passafaro, Emilio Hirsch, Giorgio R. Merlo
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:International Journal of Molecular Sciences
Subjects:
RhoA
Rac1
cdc42
intellectual disability
neuronal networks
GTPase pathway
Online Access:http://www.mdpi.com/1422-0067/19/6/1821

Internet

http://www.mdpi.com/1422-0067/19/6/1821

Similar Items