Positive Effects of PI3K/Akt Signaling Inhibition on PTEN and P53 in Prevention of Acute Lymphoblastic Leukemia Tumor Cells

Positive Effects of PI3K/Akt Signaling Inhibition on PTEN and P53 in Prevention of Acute Lymphoblastic Leukemia Tumor Cells

Purpose: The PI3K/Akt signaling pathway regulates cell growth, proliferation and viability in hematopoietic cells. This pathway always dysregulates in acute lymphoblastic leukemia (ALL). PTEN and P53 are tumor suppressor genes correlated with PI3K/Akt signaling pathway, and both have a tight link in...

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Bibliographic Details
Main Authors: Elahe Naderali, Behnaz Valipour, Amir Afshin Khaki, Jafar Soleymani Rad, Alireza Alihemmati, Mohammad Rahmati, Hojjatollah Nozad Charoudeh
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2019-08-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
PI3K/Akt signaling
MK-2206
BKM-120
ALL
PTEN
P53
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-25281

Internet

https://apb.tbzmed.ac.ir/PDF/apb-25281

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