The Adductomics of Isolevuglandins: Oxidation of IsoLG Pyrrole Intermediates Generates Pyrrole–Pyrrole Crosslinks and Lactams

The Adductomics of Isolevuglandins: Oxidation of IsoLG Pyrrole Intermediates Generates Pyrrole–Pyrrole Crosslinks and Lactams

Isoprostane endoperoxides generated by free radical-induced oxidation of arachidonates, and prostaglandin endoperoxides generated through enzymatic cyclooxygenation of arachidonate, rearrange nonenzymatically to isoprostanes and a family of stereo and structurally isomeric γ-ketoaldehyde se...

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Bibliographic Details
Main Authors: Wenzhao Bi, Geeng-Fu Jang, Lei Zhang, John W. Crabb, James Laird, Mikhail Linetsky, Robert G. Salomon
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:High-Throughput
Subjects:
Adductome
Covalent adducts
Electrophilic species
Mass spectrometry
Reactive metabolites
Isolevuglandins
Protein crosslinking
Online Access:https://www.mdpi.com/2571-5135/8/2/12

Internet

https://www.mdpi.com/2571-5135/8/2/12

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