Targeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation

Targeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation

Abstract Background Overexpression of AXL receptor tyrosine kinase (AXL) in various human cancers correlates with reduced patients overall survival and resistance to first line therapies. Therefore, several AXL tyrosine kinase inhibitors (TKIs) are currently under clinical evaluation. Results AXL TK...

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Bibliographic Details
Main Authors: Markus Lauter, Anja Weber, Robert Torka
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Cell Communication and Signaling
Subjects:
RTK
AXL
TKI
Ubiquitin
Degradation
3D spheroid
Online Access:http://link.springer.com/article/10.1186/s12964-019-0377-8

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http://link.springer.com/article/10.1186/s12964-019-0377-8

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