Evidence of positively selected G6PD A‐ allele reduces risk of Plasmodium falciparum infection in African population on Bioko Island

Evidence of positively selected G6PD A‐ allele reduces risk of Plasmodium falciparum infection in African population on Bioko Island

Abstract Background Glucose‐6‐phosphate dehydrogenase (G6PD) is an essential enzyme that protects red blood cells from oxidative damage. Although G6PD‐deficient alleles appear to confer a protective effect of malaria, the link with clinical protection against Plasmodium infection is conflicting. Met...

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Bibliographic Details
Main Authors: Xue‐Yan Liang, Jiang‐Tao Chen, Yan‐Bo Ma, Hui‐Ying Huang, Dong‐De Xie, Santiago‐m Monte‐Nguba, Carlos Salas Ehapo, Urbano Monsuy Eyi, Yu‐Zhong Zheng, Xiang‐Zhi Liu, Guang‐Cai Zha, Li‐Yun Lin, Wei‐Zhong Chen, Xia Zhou, Min Lin
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
EHH
G6PD (A‐) deficiency
malaria
natural selection
Online Access:https://doi.org/10.1002/mgg3.1061

Internet

https://doi.org/10.1002/mgg3.1061

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