Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs

Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs

Tregs are crucial for maintaining maternal immunotolerance against the semiallogeneic fetus. We investigated the elusive transcriptional profile and functional adaptation of human uterine Tregs (uTregs) during pregnancy. Uterine biopsies, from placental bed (materno-fetal interface) and incision sit...

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Bibliographic Details
Main Authors: Judith Wienke, Laura Brouwers, Leone M. van der Burg, Michal Mokry, Rianne C. Scholman, Peter G.J. Nikkels, Bas B. van Rijn, Femke van Wijk
Format: Article
Language:English
Published: American Society for Clinical investigation 2020-09-01
Series:JCI Insight
Subjects:
Immunology
Reproductive biology
Online Access:https://doi.org/10.1172/jci.insight.137926

Internet

https://doi.org/10.1172/jci.insight.137926

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