α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Abstract Background Neuroinflammation has an essential impact on the pathogenesis and progression of Alzheimer’s disease (AD). Mostly mediated by microglia and astrocytes, inflammatory processes lead to degeneration of neuronal cells. The NLRP3-inflammasome (NOD-like receptor family, pyrin domain co...

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Bibliographic Details
Main Authors: Taraneh Ebrahimi, Marcus Rust, Sarah Nele Kaiser, Alexander Slowik, Cordian Beyer, Andreas Rembert Koczulla, Jörg B. Schulz, Pardes Habib, Jan Philipp Bach
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
NLRP3
NALP3
Inflammasome
Alzheimer’s disease
Amyloid β
Online Access:http://link.springer.com/article/10.1186/s12974-018-1319-x

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http://link.springer.com/article/10.1186/s12974-018-1319-x

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