Fusion with extracellular domain of cytotoxic T-lymphocyte-associated-antigen 4 leads to enhancement of immunogenicity of Hantaan virus DNA vaccines in C57BL/6 mice

Fusion with extracellular domain of cytotoxic T-lymphocyte-associated-antigen 4 leads to enhancement of immunogenicity of Hantaan virus DNA vaccines in C57BL/6 mice

<p>Abstract</p> <p>Background</p> <p>Hantaan virus (HTNV) is the causative agent of the most severe form of a rodent-borne disease known as hemorrhagic fever with renal syndrome (HFRS). A safe and effective HTNV vaccine is needed. Vaccination with DNA constructs express...

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Bibliographic Details
Main Authors: Wang Shiwen, Zhang Shuo, Li Chuan, Zhang Quanfu, Liu Qinzhi, Cao Shouchun, Liang Mifang, Liu Feng, Li Dexin
Format: Article
Language:English
Published: BMC 2011-09-01
Series:Virology Journal
Online Access:http://www.virologyj.com/content/8/1/448

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http://www.virologyj.com/content/8/1/448

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