Interaction of the Human Papillomavirus E1 Helicase with UAF1-USP1 Promotes Unidirectional Theta Replication of Viral Genomes

Human papillomaviruses (HPVs) are important pathogens that replicate their double-stranded circular DNA genome in the nucleus of infected cells. HPV genomes replicate in infected cells via bidirectional theta replication and a poorly understood unidirectional mechanism, and the onset of viral replic...

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Bibliographic Details
Main Authors: Marit Orav, David Gagnon, Jacques Archambault
Format: Article
Language:English
Published: American Society for Microbiology 2019-03-01
Series:mBio
Subjects:
Online Access:https://doi.org/10.1128/mBio.00152-19