68Ga, 44Sc and 177Lu-labeled AAZTA5-PSMA-617: synthesis, radiolabeling, stability and cell binding compared to DOTA-PSMA-617 analogues

68Ga, 44Sc and 177Lu-labeled AAZTA5-PSMA-617: synthesis, radiolabeling, stability and cell binding compared to DOTA-PSMA-617 analogues

Abstract Background The AAZTA chelator and in particular its bifunctional derivative AAZTA5 was recently investigated to demonstrate unique capabilities to complex diagnostic and therapeutic trivalent radiometals under mild conditions. This study presents a comparison of 68Ga, 44Sc and 177Lu-labeled...

Full description

Bibliographic Details
Main Authors: Jean-Philippe Sinnes, Ulrike Bauder-Wüst, Martin Schäfer, Euy Sung Moon, Klaus Kopka, Frank Rösch
Format: Article
Language:English
Published: SpringerOpen 2020-11-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Scandium-44
Lutetium-177
Gallium-68
AAZTA
AAZTA5-PSMA-617
PSMA-617
Online Access:http://link.springer.com/article/10.1186/s41181-020-00107-8

Internet

http://link.springer.com/article/10.1186/s41181-020-00107-8

Similar Items