Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab

Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab

Abstract Background Monoclonal antibodies (mAbs) and their derivatives have become one of the most important classes of therapeutic drugs. Their multiple applications increased the interest for understanding their complex structure. In vivo, animal cells are able to fold mAbs correctly (Song et al,...

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Bibliographic Details
Main Authors: Mercè Farràs, Ramón Román, Marc Camps, Joan Miret, Óscar Martínez, Xavier Pujol, Antoni Casablancas, Jordi Joan Cairó
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Molecular and Cell Biology
Subjects:
mAb
Protein structure
Folding
Disulfide bonds
Renaturalization
LC
Online Access:https://doi.org/10.1186/s12860-019-0244-x

Internet

https://doi.org/10.1186/s12860-019-0244-x

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