Sialyl residues modulate LPS-mediated signaling through the Toll-like receptor 4 complex.

Sialyl residues modulate LPS-mediated signaling through the Toll-like receptor 4 complex.

We previously reported that neuraminidase (NA) pretreatment of human PBMCs markedly increased their cytokine response to lipopolysaccharide (LPS). To study the mechanisms by which this occurs, we transfected HEK293T cells with plasmids encoding TLR4, CD14, and MD2 (three components of the LPS recept...

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Main Authors: Chiguang Feng, Nicholas M Stamatos, Anatoliy I Dragan, Andrei Medvedev, Melissa Whitford, Lei Zhang, Chang Song, Prasad Rallabhandi, Leah Cole, Quan M Nhu, Stefanie N Vogel, Chris D Geddes, Alan S Cross
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3322133?pdf=render

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http://europepmc.org/articles/PMC3322133?pdf=render

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