Essential role for autophagy protein VMP1 in maintaining neuronal homeostasis and preventing axonal degeneration

Essential role for autophagy protein VMP1 in maintaining neuronal homeostasis and preventing axonal degeneration

Abstract Vacuole membrane protein 1 (VMP1), the endoplasmic reticulum (ER)-localized autophagy protein, plays a key role during the autophagy process in mammalian cells. To study the impact of VMP1-deficiency on midbrain dopaminergic (mDAergic) neurons, we selectively deleted VMP1 in the mDAergic ne...

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Bibliographic Details
Main Authors: Panpan Wang, Xi Chen, Yuanyuan Wang, Congcong Jia, Xinyao Liu, Ying Wang, Haifeng Wu, Huaibin Cai, Han-Ming Shen, Weidong Le
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03412-5

Internet

https://doi.org/10.1038/s41419-021-03412-5

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