Designed whole-cell-catalysis-assisted synthesis of 9,11-secosterols

Designed whole-cell-catalysis-assisted synthesis of 9,11-secosterols

A method for the synthesis of 9,11-secosteroids starting from the natural corticosteroid cortisol is described. There are two key steps in this approach, combining chemistry and synthetic biology. Stereo- and regioselective hydroxylation at C9 (steroid numbering) is carried out using whole-cell bioc...

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Bibliographic Details
Main Authors: Marek Kõllo, Marje Kasari, Villu Kasari, Tõnis Pehk, Ivar Järving, Margus Lopp, Arvi Jõers, Tõnis Kanger
Format: Article
Language:English
Published: Beilstein-Institut 2021-03-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
chemoenzymatic synthesis
cortisol
hydroxylation
secosterol
whole-cell catalysis
Online Access:https://doi.org/10.3762/bjoc.17.52

Internet

https://doi.org/10.3762/bjoc.17.52

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