A non-viral genome editing platform for site-specific insertion of large transgenes

A non-viral genome editing platform for site-specific insertion of large transgenes

Abstract Background The precise, functional and safe insertion of large DNA payloads into host genomes offers versatility in downstream genetic engineering-associated applications, spanning cell and gene therapies, therapeutic protein production, high-throughput cell-based drug screening and reporte...

Full description

Bibliographic Details
Main Authors: Namrata Chaudhari, Amanda M. Rickard, Suki Roy, Peter Dröge, Harshyaa Makhija
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Stem Cell Research & Therapy
Subjects:
Genome engineering
Gene therapy
Embryonic stem cells
Large transgene
FVIII clotting protein
Lambda integrase
Online Access:http://link.springer.com/article/10.1186/s13287-020-01890-6

Internet

http://link.springer.com/article/10.1186/s13287-020-01890-6

Similar Items