Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells

Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells

Background Autologous T cells engineered to express a chimeric antigen receptor (CAR) specific for CD19 molecule have transformed the therapeutic landscape in patients with highly refractory leukemia and lymphoma, and the use of donor-generated allogeneic CAR T is paving the way for further breakthr...

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Bibliographic Details
Main Authors: Carl H June, David M Barrett, Stephan A Grupp, Rong Fan, Marcela V Maus, Zhiliang Bai, Stefan Lundh, Dongjoo Kim, Steven Woodhouse, Regina M Myers, Pablo G Camara, J Joseph Melenhorst
Format: Article
Language:English
Published: BMJ Publishing Group 2021-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/5/e002328.full

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https://jitc.bmj.com/content/9/5/e002328.full

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