Implementation of Glycan Remodeling to Plant-Made Therapeutic Antibodies

Implementation of Glycan Remodeling to Plant-Made Therapeutic Antibodies

N-glycosylation profoundly affects the biological stability and function of therapeutic proteins, which explains the recent interest in glycoengineering technologies as methods to develop biobetter therapeutics. In current manufacturing processes, N-glycosylation is host-specific and remains difficu...

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Bibliographic Details
Main Authors: Lindsay D. Bennett, Qiang Yang, Brian R. Berquist, John P. Giddens, Zhongjie Ren, Vally Kommineni, Ryan P. Murray, Earl L. White, Barry R. Holtz, Lai-Xi Wang, Sylvain Marcel
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:International Journal of Molecular Sciences
Subjects:
glycan remodeling
therapeutic proteins
recombinant glycoproteins
Nicotiana benthamiana
N-glycosylation
Online Access:http://www.mdpi.com/1422-0067/19/2/421

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http://www.mdpi.com/1422-0067/19/2/421

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