Efficient and Highly Specific Gene Transfer Using Mutated Lentiviral Vectors Redirected with Bispecific Antibodies

Efficient and Highly Specific Gene Transfer Using Mutated Lentiviral Vectors Redirected with Bispecific Antibodies

The goal of gene therapy is specific delivery and expression of therapeutic genes to target cells and tissues. Common lentivirus (LV) vectors are efficient gene delivery vehicles but offer little specificity. Here, we report an effective and versatile strategy to redirect LV to target cells using bi...

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Bibliographic Details
Main Authors: Christina L. Parker, Timothy M. Jacobs, Justin T. Huckaby, Dimple Harit, Samuel K. Lai
Format: Article
Language:English
Published: American Society for Microbiology 2020-01-01
Series:mBio
Subjects:
lentivirus
bispecific antibody
gene therapy
sindbis
targeted gene delivery
Online Access:https://doi.org/10.1128/mBio.02990-19

Internet

https://doi.org/10.1128/mBio.02990-19

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