Polymer stealthing and mucin-1 retargeting for enhanced pharmacokinetics of an oncolytic vaccinia virus

Polymer stealthing and mucin-1 retargeting for enhanced pharmacokinetics of an oncolytic vaccinia virus

Vaccinia virus (VV) is a powerful tool for cancer treatment with the potential for tumor tropism, efficient cell-to-cell spread, rapid replication in cancer cells, and stimulation of anti-tumor immunity. It has a well-defined safety profile and is being assessed in late-stage clinical trials. Howeve...

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Bibliographic Details
Main Authors: Claudia Hill, Megan Grundy, Luca Bau, Sheena Wallington, Joel Balkaran, Victor Ramos, Kerry Fisher, Len Seymour, Constantin Coussios, Robert Carlisle
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
vaccinia virus
oncolytic virotherapy
polymer coating
cholesterol-PEG
targeting
mucin-1
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521000449

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http://www.sciencedirect.com/science/article/pii/S2372770521000449

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